The launch, if confirmed, highlights rapidly rising tensions in the 33-month-old war after Ukraine fired US and British missiles at targets inside Russia this week despite warnings by Moscow that it would see such action as a major escalation.
France currently has no evidence that Russia launched an intercontinental ballistic missile (ICBM) to attack Ukraine on 21 November, but it does talk of Moscow's "continued escalation".
A rehabilitation center for people with disabilities was damaged following a Russian missile attack on the Ukrainian city of Dnipro on Thursday.
This comes after Ukraine fired American-supplied long-range missiles into Russia on Tuesday, marking the first time for Kyiv to do so in the 1,000 days of war – a move that was authorized by President Biden on Sunday.